Dental OCT

Dental Applications of Optical Coherence Tomography (OCT) in Cariology

Across all medical disciplines, therapeutic interventions are based on previously acquired diagnostic information. In cariology, which includes the detection and assessment of the disease “caries” and its lesions, as well as non-invasive to invasive treatment and caries prevention, visual inspection and radiology are routinely used as diagnostic tools. However, the specificity and sensitivity o...

Swept-Source OCT Angiography: SS OCT AngioTM

Towards early dental caries detection with OCT and polarized Raman spectroscopy

In recent years, we have been developing optical coherence tomography (OCT) and polarized Raman spectroscopy (PRS) for the detection of early noncavitated dental caries. OCT provides high resolution morphological depth imaging of incipient caries. With OCT, early lesions can be readily identified as regions of high light backscattering with depth into the enamel as compared to health sound enam...

XPC Promotes Pluripotency of Human Dental Pulp Cells through Regulation of Oct-4/Sox2/c-Myc.

Introduction. Xeroderma pigmentosum group C (XPC), essential component of multisubunit stem cell coactivator complex (SCC), functions as the critical factor modulating pluripotency and genome integrity through interaction with Oct-4/Sox2. However, its specific role in regulating pluripotency and multilineage differentiation of human dental pulp cells (DPCs) remains unknown. Methods. To elucidat...

Mouse Oct-1 contains a composite homeodomain of human Oct-1 and Oct-2.

Members of the Oct family of transcription factors specifically interact with the octamer motif, ATGC-AAAT, a regulatory element important for tissue- and cell-specific transcription as well as for the expression of housekeeping genes. Except for Oct-1, all Oct factors are expressed in a temporally and spatially restricted mode during murine development and their number varies in a given cell t...